1-(Prop-2-yn-1-yl)piperidine → HCID 67347544, compound

Participants

Reaction Conditions

Reaction Steps

Prepared from 1-(prop-2-ynyl)piperidine (24 mg, 0.19 mmol) and 3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)benzenamine (Example 6, Step A; 50 mg, 0.13 mmol) according to the procedure described for Example 6, Step B, except the reaction was heated at 50° C. for 5 hours. The crude was purified by preparative TLC [5% MeOH (containing 7N NH3) in CHCl3]. The product was obtained as a waxy solid (41 mg, 71%). 1H NMR (400 MHz, CDCl3) δ 8.47 (d, J=6 Hz, 1H), 7.58 (s, 1H), 7.03 (t, J=9 Hz, 1H), 6.52 (m, 3H), 3.85 (br s, 2H), 3.56 (s, 2H), 2.60 (m, 4H), 1.66 (m, 4H), 1.47 (m, 2H).

Provenance & Evidence