3-Fluoro-4-((2-iodothieno[3,2-b]pyridin-7-yl)oxy)aniline → HCID 67348983, compound

Participants

Reaction Conditions

Reaction Steps

Prepared from N,N-dimethyl-1-(prop-2-ynyl)piperidin-4-amine (32 mg, 0.19 mmol) and 3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)benzenamine (Example 6, Step A; 50 mg, 0.13 mmol) according to the procedure described for Example 6, Step B, except the reaction was heated at 50° C. for 7 hours. The crude was partially purified by preparative TLC [5% MeOH (containing 7N NH3) in CH2Cl2]. The product was obtained as a waxy solid (34 mg, 31%; 50% purity by 1H NMR), and carried forward without further purification. LRMS (APCI pos) m/e 425 (M+1).

Provenance & Evidence