3-Fluoro-4-((2-iodothieno[3,2-b]pyridin-7-yl)oxy)aniline → HCID 67347409, compound

Participants

Reaction Conditions

Reaction Steps

Prepared from 1-(prop-2-ynyl)-4-(trifluoromethyl)piperidin-4-ol (40 mg, 0.19 mmol) and 3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)benzenamine (Example 6, Step A; 50 mg, 0.13 mmol) according to the procedure described for Example 6, Step B, except the reaction was heated at 50° C. for 7 hours. The crude was partially purified by preparative TLC [5% MeOH (containing 7N NH3) in CH2Cl2]. The product was obtained as a waxy solid (24 mg) and carried forward without further purification,

Provenance & Evidence