Dietylaminopropin → HCID 67347565, compound

Participants

Reaction Steps

Prepared from 4-(2-iodothieno[3,2-b]pyridin-7-yloxy)benzenamine (Example 72, Step A; 130 mg, 0.353 mmol), and N,N-diethylprop-2-yn-1-amine (58.9 mg, 0.530 mmol), according to the procedure for Example 6, Step B. The product was purified by Biotage 40S column (EtOAc). Product was an orange oil which crystallized upon standing (40 mg, 31%). 1H NMR (CDCl3, 400 MHz) δ 8.46 (d, J=5.5 Hz, 1H), 7.57 (s, 1H), 6.96 (d, J=9 Hz, 2H), 6.72 (d, J=9 Hz, 2H), 6.52 (d, J=5 Hz, 1H), 3.77 (s, 2H), 3.71 (s, 2H), 2.64 (q, J=7, 14 Hz, 4H), 1.13 (t, J=7 Hz, 6H). LRMS (ESI pos) m/e 352 (M+1).

Provenance & Evidence