Trifluoroacetic acid → HCID 86614646, compound

Participants

Reaction Steps

To a stirred solution of tert-butyl 4-(2-(4-(2-(3-(diethylamino)prop-1-ynyl)thieno[3,2-b]pyridin-7-yloxy)-3-fluorophenylamino)-2-oxoethyl)piperidine-1-carboxylate (Example 35; 2 mg, 0.00336 mmol) in methylene chloride (3 mL) was added 2,2,2-trifluoroacetic acid (3.83 mg, 0.0336 mmol). The reaction was stirred for 4 hours at room temperature. The reaction mixture was concentrated to dryness to give the product as a clear oil. Yield: 1.2 mg (47%). LRMS (esi pos) m/e 495 (M+1).

Provenance & Evidence