Phenylacetyl isothiocyanate → 1-(3-Fluoro-4-(2-(2-furyl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-3-(2-phenylacetyl)thiourea

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Reaction Steps

Prepared from 3-fluoro-4-(2-(furan-2-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine (100 mg, 0.306 mmol) obtained in Step A and 2-phenylethanoyl isothiocyanate (109 mg, 0.613 mmol; prepared according to the procedure described by J. Org. Chem. 1964, 29, 1115-1119) using the procedure described for Example 96, Step D. Collected the product (6 mg, 4%) as a white solid. 1H NMR (CDCl3, 400 MHz) δ 12.6 (s, 1H), 8.53 (s, 1H), 8.39 (d, J=6.6 Hz, 1H), 8.07 (d, J=13.2 Hz, 1H), 7.90 (s, 1H), 7.61 (d, J=6.2 Hz, 1H), 7.44 (m, 7H), 7.04 (s, 1H), 6.73 (d, J=6.2 Hz, 1H), 6.62 (s, 1H), 3.78 (s, 2H). LRMS (APCI+) m/e 504 (M+1) detected.

Provenance & Evidence