HCID 66767137, compound → HCID 58949426, compound

Participants

Reaction Steps

Prepared from 3-fluoro-4-(2-(3-(4-methylpiperazin-1-yl)prop-1-ynyl)thieno[3,2-b]pyridin-7-yloxy)aniline (Example 17, Step B) and 2-(4-fluorophenyl)-6-methyl-3-oxo-2,3-dihydropyridazine-4-carboxylic acid according to the procedure of Example 89. The crude was purified by silica gel flash column chromatography (5% MeOH in CH2Cl2) to afford 4.5 mg (14%) of the desired product. LRMS (ESI pos) m/e 627.3 (M+1). 1H-NMR (400 MHz, CDCl3/CD3OD) δ 8.47 (d, 1H), 8.32 (s, 1H), 8.0 (dd, 1H), 7.62 (m, 3H), 7.45 (d, 1H), 7.34 (t, 1H), 7.27 (t, 2H), 6.65 (d, 1H), 3.66 (s, 2H), 2.77 (m, 8H), 2.56 (s, 3H), 2.34 (s, 3H); 19F NMR (376 MHz, CDCl3/CD3OD) δ −113.2, −127.6.

Provenance & Evidence