Tert-butyl 4-(prop-2-yn-1-yl)piperidine-1-carboxylate → HCID 67349366, compound

Participants

Reaction Steps

Prepared from N-(3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide (Example 12, Step A, 50 mg, 0.0845 mmol) and tert-butyl 4-(prop-2-ynyl)piperidine-1-carboxylate (37.8 mg, 0.169 mmol) using the procedure described for Example 6, Step B. The reaction was purified by preparative TLC (1 mm thickness, Rf=0.52), eluting with 10% MeOH/DCM. The product was subject to a second preparative TLC purification (0.5 mm thickness, Rf=0.09), eluting with 1:1 EtOA/hexanes. The product was obtained as a beige powder (25 mg, 31%). LRMS (APCI−): m/z 685 (M−1) detected.

Provenance & Evidence