反应详情

温度

100 °C

A round-bottomed flask was charged with N-(3-fluoro-4-(2-iodothieno[3,2-b]pyridin-7-yloxy)phenyl)-2-oxopyrrolidine-3-carboxamide (15.0 mg, 0.030 mmol), 4-(methyl carbamoyl)phenylboronic acid (16.2 mg, 0.091 mmol), tetrakis(triphenylphosphine)palladium (6.97 mg, 0.0060 mmol), Na2CO3 (0.0754 ml, 0.15 mmol) and DME (10 mL). The reaction mixture was stirred at 100° C. until the starting material had been consumed (4 hours). Then the reaction mixture was cooled to room temperature and partitioned between EtOAc (100 mL) and H2O (100 mL). The phases were separated and the aqueous phase was re-extracted with EtOAc (3×100 mL). The combined organic layers were dried (Na2SO4), filtered and concentrated to yield a crude product. The crude product was purified by silica gel chromatography (DCM/7 M NH3 in MeOH from 50/1 to 10/1, v/v) to give product (3.6 mg, 23.7%). LRMS (APCI pos): >99% purity, 254 nm, m/e 505 (M+1). 1H NMR (400 MHz, CD3OD) δ 8.47 (d, 1H), 7.84-8.00 (m, 6H), 7.32-7.46 (m, 2H), 6.65 (d, 1H), 3.38-3.56 (m, 3H), 2.95 (s, 3H), 2.34-2.62 (m, 2H).

1. customhad been consumed (4 hours)
2. temperatureThen the reaction mixture was cooled to room temperature
3. custompartitioned between EtOAc (100 mL) and H2O (100 mL)
4. customThe phases were separated
5. extractionthe aqueous phase was re-extracted with EtOAc (3×100 mL)
6. dry with materialThe combined organic layers were dried (Na2SO4)
7. filtrationfiltered
8. concentrationconcentrated
9. customto yield a crude product
10. customThe crude product was purified by silica gel chromatography (DCM/7 M NH3 in MeOH from 50/1 to 10/1