4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-N-methylbenzamide → 4-(7-(2-Fluoro-4-(1-(4-fluorophenyl)-6-oxo-1,6-dihydropyridazine-5-carboxamido)phenoxy)thieno[3,2-b]pyridin-2-yl)benzoic acid

Participants

Reaction Steps

Prepared according to the procedure for Example 112, Step B substituting 4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)benzoic acid (1.25 g, 3.29 mmol) for 4-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)-N-methylbenzamide and 2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carbonyl fluoride (1.70 g, 5.75 mmol) for 1-((4-fluorophenyl)carbamoyl)cyclopropanecarbonyl fluoride. When the reaction was complete, water (20 mL) was added and the product (1.59 g, 80%) was collected by filtration to get a brown solid. LRMS (esi+) 597 m/z (M+1) detected.

Provenance & Evidence