反应详情

A mixture of 5-(2,5-difluoro-4-hydroxyphenyl)-3-methyl-2-(phenylamino)pyrimidin-4(3H)-one (0.031 g, 0.093 mmol), 7-chloro-2-iodothieno[3,2-b]pyridine (0.025 g, 0.085 mmol; prepared according to the procedure of Ragan, J. A. Org. Proc. Res. 2003, 7, 676) and DMAP (0.010 g, 0.085 mmol) in bromobenzene (1.5 mL) under nitrogen was stirred at 150° C. for 6 days. The reaction was concentrated in vacuo to remove as much bromobenzene as possible and then purified directly by flash column chromatography, eluting with 20:1 CH2Cl2/MeOH. The product was obtained (10.5 mg; 21%) as a yellow solid. LRMS (APCI pos) m/e 589 (M+1).

1. customprepared
2. concentrationThe reaction was concentrated in vacuo
3. customto remove as much bromobenzene as possible and
4. customthen purified directly by flash column chromatography
5. washeluting with 20:1 CH2Cl2/MeOH
6. customThe product was obtained (10.5 mg; 21%) as a yellow solid