2-(4-Fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid → HCID 67347435, compound

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Reaction Steps

Prepared from 7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridine-2-carbonitrile and 2-(4-fluorophenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (Example 104, Step C) according to the procedure of Example 89. The crude was purified by silica gel flash column chromatography (5% MeOH in CH2Cl2) to afford 73 mg (83%) of the desired product. LRMS (APCI pos) m/e 502.2 (M+1). 1H-NMR (400 MHz, CDCl3) δ 11.89 (s, 1H), 8.64 (d, 1H), 8.42 (d, 1H), 8.25 (d, 1H), 8.11 (s, 1H), 7.99 (dd, 1H), 7.60 (m, 2H), 7.43 (d, 1H), 7.27 (m, 3H), 7.67 (d, 1H); 19F NMR (376 MHz, CDCl3/CD3OD) δ −111.3, −126.0.

Provenance & Evidence