反应详情

To the mixture of 36 g (0.3 mole) benzotriazole and 30 mL (0.3 mole) of cyclopentylamine in 1400 mL of ether was added dropwise 22 mL (0.3 mole) of 37% aqueous formaldehyde. The reaction mixture was stirred at room temperature overnight. The solution was dried over calcium chloride, filtered and concentrated under pressure. Hexane was added to the residue cooled in an ice bath and the resulting solid was collected by filtration washing with hexane and then dried to give 58.6 g of benzotriazol-1-ylmethyl-cyclopentylamine as a white solid.

1. dry with materialThe solution was dried over calcium chloride
2. filtrationfiltered
3. concentrationconcentrated under pressure
4. additionHexane was added to the residue
5. temperaturecooled in an ice bath
6. filtrationthe resulting solid was collected by filtration
7. washwashing with hexane
8. customdried