反应详情

To a mixture of 54 g (0.45 mole) benzotriazole and 51.5 mL (0.45 mole) of cyclohexylamine in 2000 mL of ether was added dropwise 36.5 mL (0.45 mole) of 37% aqueous formaldehyde. The reaction mixture was stirred at room temperature for 18 hours. The mixture was dried over calcium chloride, filtered and concentrated under reduced pressure. 200 mL of hexanes was added to the residue and the resulting solid collected by filtration, washed with 300 mL of hexane to give 90.0 g of benzotriazol-1-ylmethyl-cyclohexylamine as a white solid.

1. dry with materialThe mixture was dried over calcium chloride
2. filtrationfiltered
3. concentrationconcentrated under reduced pressure
4. addition200 mL of hexanes was added to the residue
5. filtrationthe resulting solid collected by filtration
6. washwashed with 300 mL of hexane