反应详情

To a mixture of 12 g (0.1 mole) benzotriazole and 13 g (0.1 mole) of 2-thiophen-2-yl-ethylamine in 500 mL of ether was added dropwise 7.4 mL (0.1 mole) of 37% aqueous formaldehyde. The reaction mixture was stirred at room temperature overnight. The solution was dried over calcium chloride, filtered and concentrated under pressure. Hexane was added to the residue cooled in an ice bath and the resulting solid was collected by filtration, washing with hexane and then dried to give 26.0 g of benzotriazol-1-ylmethyl-(2-thiophen-2-yl-ethyl)-amine as a light yellow oil (100%).

1. dry with materialThe solution was dried over calcium chloride
2. filtrationfiltered
3. concentrationconcentrated under pressure
4. additionHexane was added to the residue
5. temperaturecooled in an ice bath
6. filtrationthe resulting solid was collected by filtration
7. washwashing with hexane
8. customdried