反应详情

To the mixture of 36 g (0.3 mole) of benzotriazole and 30 mL (0.3 mole) of cyclopentylamine in 1400 mL of ether was added dropwise 22 mL (0.3 mole) of 37% aqueous formaldehyde. The reaction mixture was stirred at room temperature overnight. The solution was dried over calcium chloride, filtered and concentrated under pressure. Hexane was added under ice-cooled bath and the resulting solid was collected by filtration and washed with hexane dried to give 58.6 g of benzotriazol-1-ylmethyl-cyclopentyl-amine as a white solid.

1. dry with materialThe solution was dried over calcium chloride
2. filtrationfiltered
3. concentrationconcentrated under pressure
4. additionHexane was added under ice-
5. temperaturecooled bath
6. filtrationthe resulting solid was collected by filtration
7. washwashed with hexane
8. customdried