反应详情

To a solution of 1.2 g (3.6 mmole) of 3-isopropoxy-N-(1-methyl-piperidin-4-yl)-4-nitro-benzamide in 25 mL of methanol was added 0.12 g of 10% palladium on carbon. The hydrogenation reaction was carried out under 50 psi of hydrogen for 2 hours. The mixture was filtered, concentrated under reduced pressure and triturated with ether. The solid was collected by filtration, washed with ether and dried under vacuum to give 1.0 g of 4-amino-3-isopropoxy-N-(1-methyl-piperidin-4-yl)-benzamide as a white solid.

1. customThe hydrogenation reaction
2. filtrationThe mixture was filtered
3. concentrationconcentrated under reduced pressure
4. customtriturated with ether
5. filtrationThe solid was collected by filtration
6. washwashed with ether
7. customdried under vacuum