2-Aminopyrimidine-5-boronic acid, pinacol ester → 1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone

HRID 167654Notes

Reaction equation

HRID 167654 reaction equation
[CH3:29][C:30]1([CH3:31])[C:32]([CH3:33])([CH3:34])[O:35][B:36]([c:37]2[cH:38][n:39][c:40]([NH2:43])[n:41][cH:42]2)[O:44]1.[Cl:1][c:2]1[n:3][c:4]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:22])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([C:18]([CH2:19][OH:20])=[O:21])[CH2:16][CH2:17]1)[s:10]2>>[c:2]1(-[c:37]2[cH:38][n:39][c:40]([NH2:43])[n:41][cH:42]2)[n:3][c:4]([N:23]2[CH2:24][CH2:25][O:26][CH2:27][CH2:28]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:22])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([C:18]([CH2:19][OH:20])=[O:21])[CH2:16][CH2:17]1)[s:10]2

Participants

3

Reactant 2

HCID 177502122-Aminopyrimidine-5-boronic acid, pinacol esterHCID 866235181-(4-((2-Chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone

Product 1

HCID 566487581-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxyethanone

Sources & evidence

ORD record
ord-615fd66d276745a0b958bf7de6b42c03
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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