Benzyloxyacetyl chloride → HCID 24772586, compound

Participants

Reaction Steps

To a mixture of 4-amino-benzoic acid methoxycarbonylmethyl ester 6 (10 grams, 47.84 mmol) and sodium bicarbonate (8 grams, 95.23 mmol) in ethyl acetate (50 mL) at 0° C. is added benzyloxy acetyl chloride (12 grams, 65.04 mmol) drop wise. The reaction mixture is stirred at room temperature for 10 hours. The solids are filtered off, and the ethyl acetate layer is washed with 5% sodium bicarbonate solution (2×25 mL), water (2×25 mL), dried over sodium sulfate, and distilled to give crude 7, which can be purified via crystallized with a suitable solvent.

Provenance & Evidence