Methyl 4-aminobenzoate → HCID 58566937, compound

Participants

Reaction Steps

To a mixture of 4-amino-benzoic acid methyl ester 11 (10 grams, 66.15 mmol) and sodium bicarbonate (11 grams, 131.67 mmol) in ethyl acetate (150 mL) at 0° C. is added benzyloxy acetyl chloride (16.6 grams, 89.93 mmol) drop wise. The reaction mixture is stirred at room temperature for 10 hours. The solids are filtered off. The ethyl acetate layer is washed with 5% sodium bicarbonate solution (2×25 mL), water (2×25 mL), dried over sodium sulfate, and distilled to get crude 12, which can be purified in a suitable solvent.

Provenance & Evidence