Diethyl Ether → Ethylmethylaminotriisopropylgermane

A solution of nBuLi (2M in hexanes, 26.34 mL, 42.14 mmol) was slowly added to an ice-cooled solution of ethylmethylamine (3.98 mL, 46.35 mmol) in ether (100 mL). The resulting white mixture was stirred for 2 hours. Triisopropylchlorogermane (9.16 mL, 42.14 mmol) was added dropwise and the reaction mixture slowly warmed to room temperature. The mixture was stirred overnight, the solvent evaporated under vacuum, and the residue washed with pentane (100 mL). The mixture was filtered through a medium glass frit under nitrogen and the solvent evaporated under vacuum to give 10.7 g, 98% of a colorless liquid. The product was purified by fractional distillation (40° C., 75 mtorr). 1H NMR (C6D6): δ 2.87 (q, 2H, 3J=6.9 Hz, NCH2CH3), 2.62 (s, 3H, NCH3), 1.36 (m, CH(CH3)2), 1.18 (d, 18H, 3J=7.2 Hz, CH(CH3)2), 1.11 (t, 3H, 3J=6.9 Hz, NCH2CH3). 13C NMR (C6D6): δ 48.42, 38.22 (NCH2CH3, NCH3), 20.19 (CH(CH3)2), 16.20, 15.79 (NCH2CH3, CH(CH3)2).

1. stirringThe mixture was stirred overnight
2. customthe solvent evaporated under vacuum
3. washthe residue washed with pentane (100 mL)
4. filtrationThe mixture was filtered through a medium glass frit under nitrogen
5. customthe solvent evaporated under vacuum

ORD record

ord-ec5946a84e7440bea667de6ed34c5731

Source dataset

uspto-grants-2011_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08008117B2