Hydrochloric Acid → HCID 54426354, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2.55 g (9.89 mmol) of (R)-2-methyl-succinic acid 1-tert-butylester 4-methyl ester in 20 ml of THF/MeOH (1/1) are added at 0° C. 10 ml (20 mmol) of 2 M sodium hydroxide. The mixture is stirred for 4 h at 0° C. and then acidified to pH 2-3 by addition of 1 M HCl. The organic solvents are evaporated. The residual aq. solution is extracted with DCM (3×30 ml), and the combined organic layers are dried over sodium sulfate and concentrated to give the product in the form of a colorless oil.

Provenance & Evidence