Bumetanide → HCID 11519146, compound

Participants

Reaction Steps

To a solution of benzyltrimethylammonium hydroxide (451 mg, 2.7 mmol) in water (1 mL) was added bumetanide (1 g, 2.7 mmol) over a period of 5 minutes. The reaction mixture became clear after 10 minutes of stirring. The water was removed under reduced pressure to yield a crude colorless oil. Pure product was obtained from recrystallization of the oil with water and heptane to yield 690 mg of benzyltrimethylammonium 3-aminosulfonyl-5-butylamino-4-phenoxybenzoate as light pink crystals.

Provenance & Evidence