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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1676916Generated: October 31, 2026

Bumetanide → HCID 16657633, compound

https://huagongshe.com/reaction/1676916

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBumetanideHCID 2471—
ReactantSodium IodideHCID 5238—
ReactantTriethylamineHCID 8471—
ReactantChloromethyl propionateHCID 221144—
SolventDimethylformamideHCID 6228—
ProductHCID 16657633HCID 16657633—

Reaction Steps

In a similar manner to Example 12, bumetanide can be reacted with chloromethyl propionate, triethylamine and sodium iodide in dimethylformamide (DMF) to yield ethylcarbonyloxymethyl 3-aminosulfonyl-5-butylamino-4-phenoxybenzoate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08008283B2
Source datasetuspto-grants-2011_08
ORD IDord-c42c640127834aaab489b5e7114cb52f
Source noteuspto-grants-2011_08