HRID1676925

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NS(=O)(=O)c1cc(C(=O)O)cc(N2CCCC2)c1Oc1ccccc1

HCID4849

Piretanide

C17H18N2O5S

HCID68166

1-Hexadecanaminium, N,N,N-trimethyl-, hydroxide (1:1)

C19H43NO

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCC[N+](C)(C)C.NS(=O)(=O)c1cc(C(=O)[O-])cc(N2CCCC2)c1Oc1ccccc1

HCID11628837

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

In a similar manner to Example 10, piretanide can be reacted with cetyltrimethylammonium hydroxide in water to yield cetyltrimethylammonium 3-aminosulfonyl-4-phenoxy-5-(1-pyrrolidinyl)benzoate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b1d7e77529624beabc0ee69e53e3ad93
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08008283B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH:1]1[CH:2]=[CH:3][C:4]([O:7][C:8]2[C:9]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:10][C:11]([C:18]([OH:20])=[O:19])=[CH:12][C:13]=2[S:14]([NH2:17])(=[O:16])=[O:15])=[CH:5][CH:6]=1.[OH-].[CH2:27]([N+:43]([CH3:46])([CH3:45])[CH3:44])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]>O>[NH2:17][S:14]([C:13]1[CH:12]=[C:11]([CH:10]=[C:9]([N:21]2[CH2:25][CH2:24][CH2:23][CH2:22]2)[C:8]=1[O:7][C:4]1[CH:5]=[CH:6][CH:1]=[CH:2][CH:3]=1)[C:18]([O-:20])=[O:19])(=[O:16])=[O:15].[CH2:27]([N+:43]([CH3:46])([CH3:44])[CH3:45])[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][CH3:42]