Furosemide → 885051-44-5

HRID 1676933Notes

Reaction equation

HRID 1676933 reaction equation
[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]([S:17]([NH2:20])(=[O:19])=[O:18])=[C:10]([Cl:21])[CH:9]=2)[O:4][CH:5]=1.[OH-].[CH2:23]([N+:30]([CH3:33])([CH3:32])[CH3:31])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[NH2:20][S:17]([C:11]1[C:10]([Cl:21])=[CH:9][C:8]([NH:7][CH2:6][C:3]2[O:4][CH:5]=[CH:1][CH:2]=2)=[C:13]([CH:12]=1)[C:14]([O-:16])=[O:15])(=[O:18])=[O:19].[CH2:23]([N+:30]([CH3:33])([CH3:32])[CH3:31])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 3440FurosemideHCID 66854Benzyltrimethylammonium hydroxide

Product 1

HCID 11547483885051-44-5

Procedure

In similar manner to Example 9, furosemide can be reacted with benzyltrimethylammonium hydroxide to yield benzyltrimethylammonium 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate.

Sources & evidence

ORD record
ord-a8ae73965b5f4450af25c45b02f0c464
Source dataset
uspto-grants-2011_08
Patent number
US08008283B2

Reaction notes

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