HRID1676934

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl

HCID3440

Furosemide

C12H11ClN2O5S

HCID68166

1-Hexadecanaminium, N,N,N-trimethyl-, hydroxide (1:1)

C19H43NO

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCC[N+](C)(C)C.NS(=O)(=O)c1cc(C(=O)[O-])c(NCc2ccco2)cc1Cl

HCID11592520

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

In similar manner to Example 10, furosemide can be reacted with cetyltrimethylammonium hydroxide in water to yield cetyltrimethylammonium 5-aminosulfonyl-4-chloro-2-[(2-furanylmethyl)amino]benzoate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4d7ef736fcd54f5c95c9d72b40b12987
来源数据集: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08008283B2
来源说明: uspto-grants-2011_08

反应 SMILES

[CH:1]1[CH:2]=[C:3]([CH2:6][NH:7][C:8]2[C:13]([C:14]([OH:16])=[O:15])=[CH:12][C:11]([S:17]([NH2:20])(=[O:19])=[O:18])=[C:10]([Cl:21])[CH:9]=2)[O:4][CH:5]=1.[OH-].[CH2:23]([N+:39]([CH3:42])([CH3:41])[CH3:40])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38]>O>[NH2:20][S:17]([C:11]1[C:10]([Cl:21])=[CH:9][C:8]([NH:7][CH2:6][C:3]2[O:4][CH:5]=[CH:1][CH:2]=2)=[C:13]([CH:12]=1)[C:14]([O-:16])=[O:15])(=[O:18])=[O:19].[CH2:23]([N+:39]([CH3:42])([CH3:40])[CH3:41])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH3:38]