1-Pyrrolidineethanamine → HCID 15950724, compound

HRID 1676940Notes

Reaction equation

HRID 1676940 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][CH:11]2[CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:9])=[CH:4][CH:3]=1.[N:21]1([CH2:26][CH2:27][NH2:28])[CH2:25][CH2:24][CH2:23][CH2:22]1>CS(C)=O>[N:21]1([CH2:26][CH2:27][NH:28][C:2]2[CH:7]=[CH:6][C:5]([C:8]([N:10]3[CH2:14][CH2:13][CH2:12][CH:11]3[CH2:15][N:16]3[CH2:20][CH2:19][CH2:18][CH2:17]3)=[O:9])=[CH:4][CH:3]=2)[CH2:25][CH2:24][CH2:23][CH2:22]1

Participants

4

Reactant 2

HCID 13441-PyrrolidineethanamineHCID 11964810(4-Fluoro-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

Product 1

HCID 15950724HCID 15950724, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

For example, (4-fluoro-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone (where Y═F) is treated with a suitable nucleophile, in this case, 2-pyrrolidin-1-yl-ethylamine in a suitable solvent such as DMSO and 33% KF/Al2O3 and the reaction is heated for 1-3 days to yield [4-(2-pyrrolidin-1-yl-ethylamino)-phenyl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone.

Workup

  1. temperaturethe reaction is heated for 1-3 days

Sources & evidence

ORD record
ord-7e692c3308df4858b6b834684f740d9f
Source dataset
uspto-grants-2011_08
Patent number
US08008296B2

Reaction notes

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