HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 15950941, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | (4-Bromo-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone | HCID 11964813 | — |
| Reactant | pyridine-4-thiol | HCID 178418431 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15950941 | HCID 15950941 | — |
Reaction Steps
For example, (4-bromo-phenyl)-(2-pyrrolidin-1-ylmethyl-pyrrolidin-yl)methanone (where Y═Br) is treated with a suitable nucleophile, in this case, 4-mercaptopyridine in a suitable solvent such as DMF with potassium carbonate and the reaction heated to reflux for 1-3 days to yield [4-(pyridin-4-ylsulfanyl)-phenyl]-(2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008296B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-546b73b1cf78403da5626245a1f9501d |
| Source note | uspto-grants-2011_08 |