Morpholine → 4-(Morpholine-4-sulfonyl)benzoic acid

HRID 1676951Notes

Reaction equation

HRID 1676951 reaction equation
Cl[S:2]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[NH:14]1[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1>>[N:14]1([S:2]([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)(=[O:4])=[O:3])[CH2:19][CH2:18][O:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 823854-(Chlorosulfonyl)benzoic acid

Product 1

HCID 5594164-(Morpholine-4-sulfonyl)benzoic acidYield 55.3%

Procedure

The title intermediate is prepared from 4-(chlorosulfonyl)benzoic acid (CAS 10130-89-9) (662 mg, 3.0 mmol) and morpholine (522 mg, 6.0 mmol) in a manner substantially similar to Procedure F to provide 450 mg (55%) of the title compound. MS (ES+) 272.3 (M+H)+.

Sources & evidence

ORD record
ord-33a3feb9486949699ef08d4dac9614fc
Source dataset
uspto-grants-2011_08
Patent number
US08008296B2

Reaction notes

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