Dichloromethane → HCID 67178111, compound

Participants

Reaction Steps

To a stirred solution of 4-methanesulfonyl-N-[4-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl]-benzenesulfonamide (Example 22) (0.028 g, 0.057 mmol) in 2 ml dichloromethane (2 mL) is added 2 M (trimethylsilyl)diazomethane in hexane (0.063 ml, 0.126 mmol) and allowed to react for 5 hours at ambient temperature. The reaction is diluted with dichloromethane and washed with 0.1 N HCl. The organic layer are dried over anhydrous sodium sulfate, filtered, and concentrated to an oily solid. The oily solid is converted to the hydrochloride salt in accordance with the preparation of the title compound of Example 23 (C-Phenyl-N-[4-(2-pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl]-methanesulfonamide; hydrochloride) to provide the title compound as a solid. MS (ES+) m/e 506.1 (M+1)+.

Provenance & Evidence