反应详情

Heat a stirring solution of 4-(3-pyridin-4-yl-propylsulfanyl)-benzoic acid methyl ester (174 mg, 0.605 mmol) (Intermediate 10) and 2N sodium hydroxide (0.42 mL, 0.848 mmol) in 1:1 tetrahydrofuran/methanol (4 ml) to reflux temperature for 18 h. The reaction is allowed to cool and then concentrated in vacuo to obtain 180 mg (99%) of the title compound. MS (ES+) m/e 274.0 (M+1)+.

1. temperatureto reflux temperature for 18 h
2. temperatureto cool
3. concentrationconcentrated in vacuo