Hydrochloric Acid → HCID 11524373, compound

Participants

Reaction Conditions

Reaction Steps

4-(3-Chloropyridin-2-yl)-N-(methoxycarbonylphenyl)-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxamide (500 mg) produced in Example 1-034 was dissolved in tetrahydrofuran (5 ml) and methanol (5 ml), 4 M sodium hydroxide solution (1 ml) was added, and the mixture was stirred at 60° C. for 5 hours. The reaction mixture was neutralized by adding 1 M hydrochloric acid and then concentrated. The concentrate was diluted with water and stirred, and white solid substance was collected by filtration and dried to obtain the title compound (433 mg)

Provenance & Evidence