Triethylamine → HCID 67372689, compound

Participants

Reaction Steps

To a solution of ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)1H-indole-2-carboxylate (101 mg, 0.219 mmol) in 2 mL of dichloromethane was added triethylamine (0.157 mL, 1.09 mmol), followed by methylamine hydrochloride(44 mg, 0.66 mmol). After one hour, the mixture was partitioned between 100 mL of EtOAc and 100 mL of saturated aqueous NH4Cl solution. The organic phase was washed with brine, dried with Na2SO4, filtered, and concentrated in vacuo to give the titled product. ESI+MS: 457.0 [M+H]−.

Provenance & Evidence