HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → 3-[(Dimethylamino)sulfonyl]-5-methoxy-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 22401482 | — |
| Reactant | HCID 86601813 | HCID 86601813 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 3-[(Dimethylamino)sulfonyl]-5-methoxy-1H-indole-2-carboxamide | HCID 10469901 | — |
Reaction Steps
Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 3-(chlorosulfonyl)-5-methoxy-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride with dimethylamine 2.0 M solution in tetrahydrofuran, and omitting triethylamine from the reaction mixture, the title compound was obtained. ESI+MS: 298.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008295B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-8ebeb4dfa5c34f8382fa0e18d0295369 |
| Source note | uspto-grants-2011_08 |