Methylamine hydrochloride → HCID 58659656, compound

HRID 1676982Notes

Reaction equation

HRID 1676982 reaction equation
ClC1C=C2[C:8](=CC=1)[N:7](S(C1C=CC=CC=1)(=O)=O)[C:6]([C:20]([O:22][CH2:23][CH3:24])=O)=C2S(Cl)(=O)=O.[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[N:35](S(C1C=CC=CC=1)(=O)=O)[C:34]([C:48]([O:50]CC)=O)=[C:33]2[S:53](Cl)(=[O:55])=[O:54].Cl.CN.C[NH:61]C1CCOC1>>[Br:29][C:30]1[CH:31]=[C:32]2[C:36](=[CH:37][CH:38]=1)[NH:35][C:34]([C:48]([NH2:61])=[O:50])=[C:33]2[S:53]([N:7]([CH3:8])[CH:6]1[CH2:24][CH2:23][O:22][CH2:20]1)(=[O:54])=[O:55]

Participants

5

Reactant 4

HCID 6364545Methylamine hydrochlorideHCID 222257063-Furanamine, tetrahydro-N-methyl-HCID 22401482ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylateHCID 86592455ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate

Product 1

HCID 58659656HCID 58659656, compound

Procedure

Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride with (±)-N-methyl-N-tetrahydrofuran-3-ylamine, the title compound was obtained.

Sources & evidence

ORD record
ord-eae5187aa2cf4be3a49d9f521052573e
Source dataset
uspto-grants-2011_08
Patent number
US08008295B2

Reaction notes

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