HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminoethanesulphonamide monohydrochloride → 3-({[2-(Aminosulfonyl)ethyl]amino}sulfonyl)-5-bromo-1H-indole-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminoethanesulphonamide monohydrochloride | HCID 3021549 | — |
| Reactant | Methylamine hydrochloride | HCID 6364545 | — |
| Reactant | ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 22401482 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592455 | — |
| Product | 3-({[2-(Aminosulfonyl)ethyl]amino}sulfonyl)-5-bromo-1H-indole-2-carboxamide | HCID 10320187 | — |
Reaction Steps
Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-bromo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride with 2-aminoethanesulfonamide hydrochloride, the title compound was obtained as a white solid. HRMS (ES) exact mass calculated for C11H13BrN4O5S2Na (M+Na+): 446.9403. Found 446.9404.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008295B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-d637191266ae40deb22a697adffc81c8 |
| Source note | uspto-grants-2011_08 |