HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 67370750, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | N-BOC-ethylenediamine | HCID 187201 | — |
| Reactant | ethyl 3-(chlorosulfonyl)-5-bromo-1-(phenylsulfonyl)-1H-indole-2-carboxylate | HCID 86592455 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67370750 | HCID 67370750 | — |
Reaction Steps
To a solution of the product from Example 3, Step A (400 mg, 0.789 mmols) in 5 mL of CH2Cl2, Boc-ethylenediamine (0.137 mL, 0.868 mmol) and triethylamine (0.22 mL, 1.6 mmol) were added. The reaction stirred at room temperature for 2 days, then poured into EtOAc, washed with saturated NaHCO3 solution and brine. The solution was dried over Na2SO4 and concentrated in vac o. Purification by flash chromatograpy using EtOAc:hexane (1:3) gave the titled compound. ESI+ MS: 530 [MH-Boc]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008295B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-bf6ccc47753043a68e7b5af994ad7448 |
| Source note | uspto-grants-2011_08 |