Triethylamine → HCID 10075053, compound

Participants

Reaction Steps

The product from Example 63 (50 mg) was combined with 4-methoxyphenyl isocyanate (21 mg) and triethylamine (58 μL) in 2 mL of dichloromethane and stirred at room temperature for 3 hours. An additional 18 μL of the isocyanate were added and the reaction stirred for 3 hours more, then diluted with EtOAc and washed with saturated NaHCO3 and brine. The solution was dried over Na2SO4 and concentrated in vacuo. The crude material was purified by preparative reversed-phase HPLC followed by triteration with Et2O/hexane to give the titled product. ESI+ MS: 510 [M+H]+

Provenance & Evidence