P-Anisidine → HCID 67373930, compound

Participants

Reaction Conditions

Reaction Steps

A solution of the material from Step A above (25 mg) was dissolved in 1 mL of THF and cooled to 0° C. Triethylamine (25 μL) was added, followed by 4 mg of triphosgene. The reaction stirred for 5 minutes at 0° C., then 5 minutes at room temperature and then was recooled to 0° C. and stirred for 5 minutes more. A solution of 4-methoxyaniline in 1 mL of THF was added slowly. The reaction was stirred for 40 minutes, diluted with EtOAc and washed with 10% citric acid solution, saturated NaHCO3 and brine. The solution was dried (Na2SO4) and concentrated in vacuo to give the titled product.

Provenance & Evidence