Methylamine hydrochloride → 5-Iodo-3-{[cyclopropyl(methyl)amino]sulfonyl}-1H-indole-2-carboxamide

Participants

Reaction Steps

Following the procedures described in Steps D and E of Example 1, replacing in Step D ethyl 5-chloro-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate with ethyl 5-iodo-3-(chlorosulfonyl)-1-(phenylsulfonyl)-1H-indole-2-carboxylate, and methylamine hydrochloride with N-cyclopropyl-N-methylammonium oxylate, the title compound was obtained. Proton NMR for the product was consistent with the titled compound. ESI+ MS: 420.16 [M+H]+.

Provenance & Evidence