Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

tert-Butyl 5-cyclopropylmethyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxylate (440 mg, 1.35 mmol) was dissolved in methanol (15 mL). 4N HCl in 1,4-dioxan (1.5 mL) was added and the mixture stirred at room temperature overnight. The solution was concentrated in vacuo, azeotroped once with toluene to give 5-cyclopropylmethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride as an off white solid (374 mg, 100% assuming HCl salt).

Provenance & Evidence