HCID 25142701, compound → HCID 25142825, compound

Participants

Reaction Steps

The (1R,2R)-2-(6-Benzyloxy-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carbonyl)-cyclohexanecarboxylic acid (1-cyano-cyclopropyl)-amide in ethyl acetate (15 mL) was hydrogenated over 5% palladium on carbon (10 mg). After an apparent uptake of 5 mL (30 min) the reaction was stopped and a sample taken for LCMS. The catalyst was filtered off and a different batch of catalyst and ethanol (5 mL) were added and the hydrogenation continued. Although there was no further uptake apparent after 3 h the reaction was stopped and LCMS indicated that the reduction had proceeded to the required product. Purified by preparative HPLC (0.5% HCOOH, CH3CN/H2O gradient) to give a white powder (34.7 mg, 43%)

Provenance & Evidence