Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | HCID 25142825 | HCID 25142825 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | HCID 25142827 | HCID 25142827 | — |
Reaction Steps
Following Example 34 (1R,2R)-2-(6-hydroxy-1,3,4,5-tetrahydro-pyrido[4,3-b]indole-2-carbonyl)-cyclohexanecarboxylic acid (1-cyano-cyclopropyl)-amide (102 mg, 0.25 mmol), bromoacetonitrile (50 uL, 0.75 mmol) and potassium carbonate (104 mg, 0.75 mmol) in DMF (5 mL) were heated to 80° C. for 1 h when reaction was ca 60% complete. Preparative HPLC (0.5% HCOOH, CH3CN/H2O gradient) to give a yellow solid (51.9, 47%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08008279B2 |
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| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-c0d397f081b1430eb9163b4f8139db39 |
|---|
| Source note | uspto-grants-2011_08 |
|---|
