tert-butyl 6-(2-(dimethylamino)ethoxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate → N,N-dimethyl-2-(2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-6-yloxy)ethanamine

Participants

Reaction Steps

tert-Butyl 6-(2-(dimethylamino)ethoxy)-3,4-dihydro-1H-pyrido[4,3-b]indole-2(5H)-carboxylate (304 mg, 0.85 mmol) was added to methanolic HCl (20 ml, reagent 10) at 0° C. under air. The resulting solution was stirred at room temperature for 19 hours. The solvent was removed under reduced pressure to afford N,N-dimethyl-2-(2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-6-yloxy)ethanamine (205 mg, 93%) as a yellow solid.

Provenance & Evidence