Ammonium Chloride → HCID 67372163, compound

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Reaction Steps

Under a nitrogen atmosphere, 4-fluorophenyl magnesium bromide (25.6 mL, 1 M tetrahydrofuran solution) was added dropwise at −40° C. into a tetrahydrofuran (100 mL) solution containing (R)-5-oxopyrrolidine-1,2-dicarboxylic acid 1-t-butyl ester 2-ethyl ester (6 g). After stirring for 1 hour at the same temperature, saturated ammonium chloride aqueous solution was added, and the resultant was extracted with ethyl acetate. After washing the organic layer with brine, the resultant was dried over anhydrous magnesium sulfate. After removing the solvent under a vacuum, the residue was purified with silica gel column chromatography, and the title compound (6.33 g) was obtained. The physical property values are as follows.

Provenance & Evidence