Hydrogen chloride-ethyl acetate → HCID 67371742, compound

Participants

Reaction Steps

A 4 N hydrochloric acid/ethyl acetate (6.8 mL) solution of (2S,5R)-2-(4-fluorophenyl)-5-((S)-1-hydroxyethyl)-pyrrolidine-1-carboxylic acid t-butyl ester (708 mg, high polarity compound) was stirred for 1 hour at room temperature. The solvent was removed under a vacuum, and 5 N sodium hydroxide was added, and extraction was conducted twice with dichloromethane. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed under a vacuum, and the title compound (479 mg) was obtained. The physical property values are as follows.

Provenance & Evidence