Hydrogen chloride-ethyl acetate → HCID 67372557, compound

Participants

Reaction Steps

4 N hydrochloric acid/ethyl acetate (7.5 mL) was added to an ethyl acetate (7.5 mL) solution of (2S,5R)-2-(4-fluorophenyl)-5-((S)-1-hydroxyethyl)-pyrrolidine-1-carboxylic acid t-butyl ester (850 mg, high polarity compound). Stirring was continued for 3 hours at room temperature. The solvent was removed under a vacuum, and sodium bicarbonate aqueous solution was added, and the resultant was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was removed under a vacuum, and the title compound (580 mg) was obtained. The physical property values are as follows.

Provenance & Evidence