Diethyl Oxalate → HCID 67370767, compound

Participants

Reaction Steps

Diethyl oxalate (5 mL) was added to (S)-1-[(2R,5S)-5-(4-chlorophenyl)pyrrolidine-2-yl]ethanol (570 mg). Stirring was continued for 2 hours at 120° C. The solvent was removed under a vacuum, and the residue was purified by silica gel column chromatography (heptane/ethyl acetate→ethyl acetate), and the title compound (470 mg) was obtained. The physical property values are as follows.

Provenance & Evidence