(3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholine-4-carboxylic acid benzyl ester → 1-[(3R,5R)-5-(3,4,5-trifluorophenyl)morpholin-3-yl]ethanone

Participants

Reaction Steps

An ethanol (15 mL) suspension of 10% palladium on carbon (50% water contain, 79.2 mg) and (3R,5R)-3-acetyl-5-(3,4,5-trifluorophenyl)morpholin-4-carboxylic acid benzyl ester (800 mg) was stirred for 15 minutes under a hydrogen atmosphere. The catalyst was separated by filtration on celite. The filtrate was concentrated, and the title compound (529 mg) was obtained. The physical property values are as follows.

Provenance & Evidence